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Chunk #30 — 3. Disruption of functional networks is associated with clinical impairment — 3.3 Parkinson's Disease and Dementia with Lewy bodies

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Functional network disruption in the degenerative dementias.
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show reduced connectivity between fronto-temporal and fronto-occipital regions compared to controls.114,118 This pattern of WM disruption is overall similar to that detected in patients with PDD,114 and AD,118 but damage in the visual association areas is more pronounced in DLB than in other dementias.114,118 Because these studies were based on patients diagnosed on clinical grounds, whereas DLB and AD pathologies often co-occur at autopsy,119 it is perhaps not surprising that efforts to date show significant overlap in the patterns of network disruption in DLB and AD.103,116,118