observed (with the highest P values at 7.45E-06), although a power analysis presented in the paper suggests that the size of the dataset would have been sufficient to detect at least one genome-wide significant (P value 5.0E-08) finding for a genetic variant with a minor allele frequency (MAF) of 0.2 causing an odds ratio of 1.3. A table in the Neale et al. paper presents the highest-ranking 25 SNPs (based on P value) (see also Table 1 in this review).Table 1Findings from TDT-based GWAS by Neale et al. (2008a), including genes in or near which the association finding is present as well information regarding the role of the gene and its possible involvement in psychiatric disordersSNPOR P valueChrPosition (bp)PositionGene functiona Additional remarksrs22954260.71031.00E-051458446208Intergenicrs96764472.0781.01E-051954116059Intron of NUCB1Nucleobindin 1, function unknown, expression in multiple organs, including brain, family member NUCB2 encodes a satiety molecule that is associated with melanocortin signaling in the hypothalamus (Oh et al. 2006)Site is known for CNVsAlso shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs23111200.67951.22E-051850628121Approximately 20 kb upstream of RAB27BRabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. RAB27B is primarily expressed in testis, but also found in brain. SNP is present
