(P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs23111200.67951.22E-051850628121Approximately 20 kb upstream of RAB27BRabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. RAB27B is primarily expressed in testis, but also found in brain. SNP is present in schizophrenia linkage region (Maziade et al. 2005)rs9646471.7171.34E-05688993111Approximately 80 kb downstream of CNR1Encodes Cannabinoid receptor 1, highly expressed in brain and earlier found associated with alcohol and drug abuse and dependence (Zuo et al. 2007) and ADHD CNR1 has earlier been shown associated with ADHD (Lu et al. 2008; Ponce et al. 2003), present in region showing suggestive linkage to ADHD in meta-analysis (Zhou et al. 2008c) and a primary linkage analysis in ADHD (Ogdie et al. 2004)Also shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs93898350.73071.58E-056141312353IntergenicAlso shows nominal association (P < 0.05) in quantitative GWAS by Lasky-Su et al. (2008b)rs8764771.9032.69E-05420766026Intron of KCNIP4Encodes Kv channel interacting protein 4 isoform 3, a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), and may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The KCNIP4 protein also interacts with presenilin. Gene is also found among top-findings from GWAS in schizophrenia
