Chunk #16 — Results — rs1395475 Genotypes in Individually Genotyped Substance Dependence versus Control Samples

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Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.

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We sought verification of the microarray-based genome scan data that used pooled DNA samples (Liu et al., 2005a,b) to identify association of rs1395475 [Figure 1(A)], by genotyping this SNP in 379 individual African–American abuser and control samples (a subset of the individuals genotyped in pools in Liu et al., 2005a,b). These results produced significant allele frequency differences in this marker, which lies in PPP3CA intron 3(χ2 = 6.07, p = .014).