Chunk #8 — METHODS AND MATERIALS — Population Outlier Exclusions

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Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.

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After removing individuals with cryptic relatedness, Golden Helix SNP and Variation Suite v7.4.0 (SVS; Golden Helix, Inc.) was used to perform a genotype principal component analysis (PCA) among all cases and controls and to plot derivative Log Ratio spread and Log Ratio average by chromosome in order to remove outlying samples (see Methods in Supplement 1).