Chunk #21 — RESULTS — Latent variable approach characterizes and ameliorates bias in GWAS of alcohol consumption

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Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts.

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For Consumption and Problems, we found that their patterns of genetic correlation with other phenotypes were much more similar than previously reported for AUDIT-C and AUDIT-P (4). Both Consumption and Problems showed strong positive genetic correlations with alcohol dependence. Consumption and Problems were also positively related to other measures of substance use (e.g. cannabis use disorder, impulsivity). Furthermore, the previous positive associations that we observed between AUDIT and indices of socioeconomic status (e.g. educational attainment) were now attenuated.