We did still observe that, compared to Consumption, Problems was more strongly related to psychopathology (e.g., post-traumatic stress disorder, depression, bipolar disorder, schizophrenia). We also identified novel divergent associations with pain phenotypes, malnutrition and measures of social satisfaction (e.g., Problems showing genetic overlap with these conditions) suggesting that, as we anticipated, the genetic contributions to alcohol consumption and misuse reflect both complementary and distinct genetic factors.
