To determine whether the differences observed in γ values reflect true differences and not artifacts of different average correlation values, we repeated our analysis by computing γ values as a function of the number of edges in the graph. Mean γ values of four anatomical regions of interest for the AD group and the control group for networks derived by thresholding the individual correlation matrices such that the network has K′ edges were computed and compared. Results were consistent with the initial analysis–significantly lower clustering coefficient values (p<0.01) in the left and right hippocampus in AD, and no significant differences in the left and right precentral gyrus.
