Similarly the best fitting model of progression of withdrawal/NA over Day 1 was a cubic polynomial with all growth parameters found to vary significantly between subjects (p’s < 0.05) shown in Figure 1B. A trend towards a significant interaction was observed between linear hours since last cigarette and smoking group (Group × Hours: B = 0.38, p = 0.06). Post-hoc tests revealed significant group difference beginning 3 hours after the last cigarette (simple effect of Group: p’s < 0.05) such that heavy smokers had significantly greater withdrawal/NA as compared to moderate smokers starting 3 hours after the last cigarette and lasting until the end of the day.
