Expression profiling was completed using Human-6 version 2 Sentrix BeadArrays (Illumina Inc.) which contains 48,702 unique probes covering 28,567 RefSeq annotated transcripts. Arrays were hybridised with labelled cRNA material and scanned according to manufacturer's instructions. The resultant data were parsed with the software package BeadStudio (Illumina Inc.) to produce raw intensity values for all probes. Signal was checked for quality using hybridisation and labelling controls internal to each array and subtracted for background within the statistical scripting environment, R v2.4.1 [31]. Signal was transformed and normalised using the variance stabilization algorithm as implemented in the vsn2 [32] Bioconductor [33] package. Transformed and normalised signal distributions for each sample were investigated with unsupervised analysis to identify outliers.
