In EAs, the association with rs1229984 (Arg48His, P = 1.17 × 10−31) was observed previously, but with much weaker significance (Bierut et al.24 reported a finding in EAs at P = 6.03 × 10−9 using their populations that we accessed for the present study). The finding with rs1789882 (Arg369Cys, P = 3.72 × 10−11) is the first GWS finding for AD in AAs, although the risk locus was known previously.25 The minor alleles for all of the GWS SNPs in the ADH gene region were protective in both populations.
