We found GWS evidence for association with AD, as a diagnosis and in symptom count ordinal trait analysis, at numerous loci, some novel. The most robust individual results were, unsurprisingly, at ADH1B, in each population, but with different functional variants. In our previous study in Han Chinese,14 our best evidence for association was at ALDH2. Considering the strongest results for these three major populations, we find evidence for convergence in terms of pathway, and sometimes even for the same gene, but not for the same variants. Thus, GWAS in different populations may be mutually informative in terms of biology, if not in terms of specific implicated risk alleles.
