As seen in males, only Ctss and Il1rn null females showed reduced ethanol intake during three consecutive days with 2 hr access to ethanol [main effect of genotype: F(1,39) = 52, p<0.001 for Ctss mice; F(1,36) = 111, p<0.001 for Il1rn mice] (Fig. 5 b,c). During 4 hr access to ethanol, female mice in both mutant strains also demonstrated reduced consumption of ethanol. Because only one-bottle is offered at a time, ethanol preference can't be measured in this test.
