Only Ctss and Il1rn null male mice showed reduced ethanol intake during three consecutive days with 2 hr access to ethanol [main effect of genotype: F(1,39) = 43, p<0.001 for Ctss mice; F(1,36) = 71, p<0.001 for Il1rn mice] (Fig. 4 b,c). During 4 hr access to ethanol, male mice of both mutant strains also demonstrated a large reduction in amount of ethanol consumed.
