Subjects were diagnosed according to the DSM-IV by a best estimate consensus process, using a DIGS, a FIGS and review of all available medical records, this best estimate procedure has been described in detail (Escamilla et al., 2007). Each best estimator was a bilingual, bicultural clinician (psychiatrist or psychologist) and cases were diagnosed independently, followed by a discussion of any differences in diagnosis, and a final consensus was completed for specific disorders, syndromes, and ages of onset. After completion of the best estimate consensus process, 518 subjects (from 284 separate families) met DSM-IV criteria for SC. Tables shown in this article are for the entire sample of affected participants. SUD was defined as either alcohol or substance abuse or dependence by best estimate consensus. Best estimators also determined age of onset of each SUD, as well as the age when each subject first met full DSM-IV criteria for SC, and whether or not each subject had ever met criteria for a full depressive episode or syndrome, using DSM-IV criteria. Best estimators independently rated the level of deterioration experienced by subjects
