The animal gene expression studies used for comparison were all P/NP studies done by our group. These included comparisons between naïve P and NP animals, as well as P animals exposed (or not) to alcohol using various models of drinking, different ages and gender. These previous studies predominantly used the hippocampus, ventral tegmental area, accumbens, amygdala or sub-regions of these areas. (Bell et al., 2009; Kimpel et al., 2007; McBride et al., 2013a; McBride et al., 2012; McBride et al., 2013b; McBride et al., 2010; Rodd et al., 2008). None examined the DRN. Genes from microarray studies using the central amygdala and the accumbens shell from these same animals (McBride et al., 2014) are noted specifically. Genes from these 3 types of analyses (GWAS, post-mortem human and P/NP animal studies) were matched to the DRN data by gene symbol.
