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Chunk #17 — 2. Materials and Methods — 2.7 Convergence Analysis

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Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.
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We assembled a list of genes that were identified in GWAS studies (Bierut et al., 2010; Edenberg et al., 2010; Hack et al., 2011; Johnson et al., 2011; Kendler et al., 2011; Lind et al., 2010; Treutlein et al., 2009; Wang et al., 2013; Zlojutro et al., 2011; Zuo et al., 2012) and postmortem studies of several brain regions. The human post-mortem studies examined superior frontal cortex (Lewohl et al., 2000; Liu et al., 2007; Liu et al., 2006), frontal cortex (Liu et al., 2007; Mayfield et al., 2002), prefrontal cortex (Flatscher-Bader et al., 2005; Iwamoto et al., 2004), temporal cortex (Sokolov et al., 2003), motor cortex (Mayfield et al., 2002) nucleus accumbens and ventral tegmental area (Flatscher-Bader et al., 2010; Flatscher-Bader et al., 2005), basolateral amygdala (Kryger and Wilce, 2010) and hippocampus (McClintick et al., 2013; Zhou et al., 2011).