Since the three genome-wide associated variants were located within an intron of DSE, this discussion has primarily focused on DSE and related gene networks. However, it should be noted that the pattern of association observed for beta EEG could implicate several nearby genes (see Figure 2); several variants in high linkage disequilbirum with rs2252790 are located within TSPYL4. For example, rs910391, which is in perfect linkage disequilbirum with rs2252790, is located in the promoter region of TSPYL4. Further, rs2252790 is nominally associated with the mRNA expression of several neighboring genes including TSPYL1, TSPYL4, ROS1, NT5DC1, and FRK, although the most robust effects were observed for DSE expression. Therefore, it is possible that associations observed in this study are due to the influence of these (or other) genes on beta EEG.
