There were few statistically significant differences in the prevalence of cannabis-related experiences across ancestries: self-reported cannabis-related paranoia was more common in the African ancestry sample than in the European ancestry sample, while cannabis-related social withdrawal was more commonly reported in the European ancestry sample. While there was no difference in associations with the measures of cannabis involvement (table 3), the schizophrenia PRS was more weakly associated with cannabis-related experiences in the African ancestry subsample of COGA relative to the European ancestry subsample, a divergence supported by significant heterogeneity tests in the meta-analysis of 2 of the 4 significant outcomes (table 4). One potential explanation for this divergence is the relatively small sample size of the African ancestry GWAS. While multi-ancestry methods like PRS-CSx have been shown to improve the predictive power of PRS in diverse samples,32 these methods still fall short of having a large, fully ancestry-matched discovery GWAS to construct SNP weights for PRS.46 It may also be the case that the relative importance of different risk factors (eg, readiness to report hallucinations and other PLEs47–49; the likelihood of
