short of having a large, fully ancestry-matched discovery GWAS to construct SNP weights for PRS.46 It may also be the case that the relative importance of different risk factors (eg, readiness to report hallucinations and other PLEs47–49; the likelihood of living in an urban area50,51; and the cumulative effects of racism and discrimination52–54) for cannabis-related experiences varies across these 2 ancestry groups in COGA. However, our study was not designed to address this question; more studies of cannabis-related psychosis risk in multi-ancestry samples and large-scale discovery of GWAS in non-European ancestries are needed.
