Following a previously described approach111, we analyzed the enrichment of gene-level associations with PTSD in genes targeted by individual drugs. We then examined the enrichment of specific drug classes among these drug target associations. We obtained gene-level associations using MAGMA31 v1.08. Variant-level associations were converted to gene-level associations using the “multi=snp-wise” model, which aggregates Z scores derived from the lowest and the mean variant-level P value within the gene boundary. We set gene boundaries 35 kb upstream and 10 kb downstream of the transcribed regions from build 37 reference data (National Center for Biotechnology Information, available at https://ctg.cncr.nl/software/magma).
