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Chunk #58 — Review

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Genome-wide association studies in ADHD.
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and primary studies (Duvall et al. 2007; Szatmari et al. 2007b)rs11646411797.40E-0616q23.381304438In intron of CDH13 Encodes cadherin 13, a member of the cadherin superfamily. The encoded protein is a calcium- dependent cell–cell adhesion glycoprotein. This particular cadherin is a putative mediator of cell–cell interaction in the heart and may act as a negative regulator of neural cell growth. Lies within the only significant linkage region for ADHD as determined in met-analysis (Zhou et al. 2008c). Has earlier shown association with metamphetamine dependence in GWAS (Uhl et al. 2008b) as well as multiple other addiction related phenotypes (Uhl et al. 2008a)Most significant finding in quantitative GWAS by Lasky-Su et al. (2008b), and shows association in the GWAS in adult ADHD by Lesch et al. (2008)rs3799977804.90E-066p21.144945334In intron of SUPT3H Encodes suppressor of Ty 3 homolog, expressed in brain and other tissues, with a potential role in transcription. The finding lies within/close to regions of suggestive linkage to ADHD (Zhou et al. 2008c) and schizophrenia (Lewis et al. 2003) from meta-analyses aWhere not indicated otherwise, the information is derived from the UCSC Browser, NCBI’s OMIM, Gene and Unigene databases, and the Sullivan Lab Evidence Project website (location of SNP expanded by ±5 Mb for