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Chunk #57 — Review

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Genome-wide association studies in ADHD.
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of Mn2+ ions (Xiang et al. 2005). Shows expression predominantly in brain and testis. Finding falls into the significant linkage region for ADHD as observed in meta-analysis (Zhou et al. 2008c)Also lies within suggestive linkage region for ADHD reported in the same publication (Lesch et al. 2008). Association also observed in the 50 K GWAS in the same publicationrs2842643703.28E-066p21.141758714Immediately upstream of TFEB Encodes transcription factor EB of unknown function. The gene is expressed in brain and many other tissues. The finding lies within/close to regions of suggestive linkage to ADHD (Zhou et al. 2008c) and schizophrenia (Lewis et al. 2003) from meta-analysesSite known for CNVsrs3893215732.56E-0511p15.117721406In intron of KCNC1 Encodes potassium voltage-gated channel Shaw-related subfamily member 1, a protein belonging to the delayed rectifier class of channel proteins and an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. The finding is present close to/within regions of (suggestive) linkage to autism from meta-analysis (Trikalinos et al. 2006) and primary studies (Duvall et al. 2007; Szatmari et al. 2007b)rs11646411797.40E-0616q23.381304438In intron of CDH13 Encodes cadherin 13, a member of the cadherin superfamily. The encoded protein is a calcium- dependent cell–cell adhesion glycoprotein. This particular cadherin is a putative mediator