the GWAS of Neale et al. (2008a) and Lasky-Su et al. (2008b)rs12453316621.72E-0517q25.169027654Within 83 kb of SDK2 Encodes sidekick homologue 2, a member of the immunoglobulin superfamily. Chicken Sdk2 mediates homophilic adhesion and direct laminar targeting of neuritesrs2237349644.63E-067p15.128729488 CREB5 Encodes cAMP-responsive element binding protein 5, which belongs to the cAMP response element (CRE)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Expressed in brain, especially fetal brain and prefrontal cortex, and other tissues. Finding is close to linkage region for neuroticism (Fullerton et al. 2003), and in a region associated with bipolar disorder in a GWAS at 10−4 (Wellcome Trust Case Control Consortium 2007). Gene shows association with schizophrenia in GWAS (Sullivan et al. 2008) at P = 10−4 rs10514604698.06E-0716q24.183003885 ATP2C2 Encodes Ca2+ transporting ATPase type 2C member 2, potentially involved in cellular detoxification of Mn2+ ions (Xiang et al. 2005). Shows expression predominantly in brain and testis. Finding falls into the significant linkage region for ADHD as observed in meta-analysis (Zhou et al. 2008c)Also lies within suggestive linkage region for ADHD reported in
