In sum, these findings demonstrate the utility of CSD in differentiating not only the alcoholics from controls but also the high-risk offspring from low risk controls in terms of strength of activations and topographic patterns derived from various paradigms. It is also clear that alcoholism is one of the clinical entities wherein CSD methods have been successfully applied in alcoholism to understand the neurocognitive deficits in AUD as reported in the literature, and also to predict risk status to develop alcoholism.