The inverse association between marriage and risk for alcohol use disorder was stronger in women than in men, with a hazard ratio of 0.27 (95% CI=0.26–0.28) (Table 3, model 1). The hazard ratio increased slightly with the addition in model 2 of birth year, parental education, early-onset externalizing behaviors, and family history. In model 3a, we see that a history of registration for alcohol use disorder in the spouse was more strongly related to risk for alcohol use disorder in women (hazard ratio=4.71) than in men. In model 3b, we can see that in women, marriage to a spouse without and a spouse with history of registration for alcohol use disorder is associated with, respectively, a substantially reduced (hazard ratio=0.25) and a modestly increased risk for alcohol use disorder (hazard ratio=1.18) compared with the nonmarried state. In model 4, we see that the reduction in risk for alcohol use disorder associated with marriage was stronger in those with a positive family history compared with those with a negative family history (hazard ratio=0.88, p=0.01).
