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Chunk #155 — ONLINE METHODS — Module Preservation Analysis

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Gene expression elucidates functional impact of polygenic risk for schizophrenia.
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As a replication of significant findings for non-preserved modules we used the microarray gene expression data from the HBCC cohort, which included 131 SCZ and 176 control samples. We used similar approaches as the ones described above to: (1) generate the null distribution of network preservation statistics in the HBCC cohort and (2) test the non-preservation of CMC significant modules in the HBCC SCZ cases vs. controls.