smoking and drinking were more frequently located about superior, middle and inferior occipital gyri. These results agree with an alcohol study by Camchong et al. (Camchong et al., 2012) where reduced connectivity within insula and within occipital gyrus was reported, but smoking was allowed among the subjects. Our observations add a reduced connectivity between sensorimotor, precuneus, occipital and insula areas to the picture. Furthermore, the magnitude of connectivity reduction between sensorimotor and visual areas was significantly associated with AUDIT score and the interaction between AUDIT and FTND. These reduced connectivity results support the idea delineated by Camchong (Camchong et al., 2012) of a link between alcohol and dysfunction in a brain network in charge of sensory awareness and attention that provides important information necessary for decision-making and assessment. Another important observation in our data is the protective effect that smoking exerted in visual memory and visual processing regions. Previous reports indicate that nicotine produce enhanced activation in the fusiform gyrus (Ghatan et al., 1998; Lawrence et al., 2002), but in our resting state results the effect might have prevented observing a difference between SAD and CTR groups. This might explain why drinkers span a larger set of visual rsFNC differences
