To investigate the functional effects of top associations (p<10−3) from the sex-stratified GWAS analysis and SDEs, we annotated each SNP as to whether it was an expression quantitative trait locus (eQTL) in brain or immune tissues. We tested for enrichment of eQTLs derived from brain tissues because brain is the primary tissue of interest, but also eQTLs derived from immune cells because the immune system has been previously implicated in several neuropsychiatric and neurodegenerative traits (Schizophrenia Working Group of the Psychiatric Genomics Consortium 2014; Marsh et al. 2016; Heneka, Golenbock, and Latz 2015; Furtado and Katzman 2015a), including OCD (Furtado and Katzman 2015b; Murphy, Sajid, and Goodman 2006)
