SDEs showed a significant enrichment for eQTLs from CD4+ T cells (p<0.001), the combination of immune tissues (p<0.002), and combined brain tissues excluding the functionally distinct cerebellum (p=0.001) (Figure 2, Supplementary Table 4). 188 eGenes were implicated by brain eQTLs and 198 by immune eQTLs, with 48 eGenes deriving from both tissues (Supplementary Table 5). Including HLA SNPs did not significantly affect the results. Consistent with the FUMA results presented above, we did not detect significant enrichments in the combined or sex-stratified analysis.
