Previous work has revealed enrichment of anthropometric traits SDEs (ASDEs) among top autism (ASD), bipolar disorder (BIP) (Mitra et al. 2016), and endometriosis (Rahmioglu et al. 2015) associated genetic variants, suggesting that the same mechanisms acting on secondary sex characteristic differences later in life may also contribute to sex differences in other complex traits, including neuropsychiatric phenotypes, via pleiotropic effects. There was little overlap and no significant enrichment (p=0.14) for ASDEs among the clumped top combined, female-specific, male-specific GWAS associations, or OCD SDEs (Supplementary Figure 9).
