As the lower bounds on the genetic correlation estimate of OCD between sexes ranged from 0.49–0.73, we explored whether males and females demonstrate differential genetic correlations between OCD and 30 traits (Supplementary Table 7) which may play a role in OCD development. Our analysis was limited by availability of combined male and female summary statistics for the majority of the traits we tested in the correlation. When available, we have used sex-stratified summary statistics to perform genetic correlation analysis between traits within each sex and assessed differences between sexes. The traits chosen for analysis included (1) neuropsychiatric phenotypes and behavioral traits (many of which exhibit sexually-differentiated characteristics), (2) traits which overlap with known sexually-differentiated clinical symptoms in OCD (e.g. smoking, eating disorders-anorexia, and body mass index), (3) brain structure volumes, and (4) reproductive behavior (age at first birth and number of children ever born).
