Using sex-stratified summary statistics for OCD and traits listed in Supplementary Table 6, we performed cross-trait genetic correlations within each sex (i.e. Rg between male OCD with male ADHD and female OCD with female ADHD). There were no significant cross-trait genetic correlations in either sex after multiple testing correction nor did the cross-trait correlations differ significantly between males and females (Supplementary Table 6), suggesting that sex stratified analyses are likely still underpowered. To increase the power of this analysis, next, we used sex-combined summary statistics for several complex traits (Supplementary Table 7) and performed cross-trait correlation analysis with sex-stratified OCD summary statistics. Several traits (bipolar disorder, schizophrenia, and neuroticism) exhibited a significant genetic correlation with female OCD, but not male OCD, again, possibly influenced by sample size (Supplementary Table 7). Again, the genetic correlations for OCD with other traits did not differ significantly between males and females.
