The level of physical activity in the 2 strata can be described by the energy expenditure at the 25th and 75th centiles of the distribution, respectively. For women, energy expenditure was 2610 and 3590 kcal/d at the 25th and 75th centiles, respectively, whereas for men energy expenditure was 3130 and 3990 kcal/d at the same centiles. Thus, in this population, a mean activity level of 860 calories for women and 980 calories for men separates the high- and low-activity strata, which differ in their phenotypic expression of the at-risk FTO genotypes.