Similarly, the rs1477196 C allele was associated with a 1.22 (0.38) increase in BMI per risk allele in the low-activity group (P =.001) but only a 0.27 (0.31) increase in BMI in the high-activity group (P =.38) (interaction P =.004) (Figure 2). The rs1477196 C allele was associated with obesity in the low-activity group (OR, 1.58 for each risk allele; P=.001) but not in the high-activity group (P =.11).