Expression of 8 out of the 12 targets was downregulated by alcohol. Two targets were upregulated, while the expression of 2 other targets was unchanged (Table 1). All ten regulated targets play important roles in different aspects of neuronal physiology (Supplementary Materials), including excitability (GABRB2, KCNMB2, CACNB1, DRD2), gene expression (CLOCK, PPARA, TGFBR2, HDAC5, CACNB1), lipid metabolism (PPARA), and function of presynaptic terminals (GABRB2, SYNJ1, CACNB1, KCNMB2). Moreover, some of these targets are known to directly regulate BK channel expression and/or function, while others could potentially contribute to that regulation (Figure 8, Supplementary Materials).
