Stroke was significantly associated with vascular smooth muscle cells (Figure 2A) consistent with an important role of vascular processes for this trait. Amyotrophic lateral sclerosis (a motor neuron disease) was significantly associated with peripheral sensory neurofilament neurons, possibly because of transcriptomic similarities between peripheral sensory and motor neurons (which were not sampled) (Figure S5). Alzheimer’s disease had the strongest signal in microglia, as reported previously11,17,31, but the association did not survive multiple testing correction.
