Of the 1,162 individuals with peer use data available, 57.5, 28.3 and 14.2% reported that none, few and most-all of their close peers used cannabis. Perceived peer cannabis use explained up to 11.3% of the variance in trajectory class membership (ORs = 1.50 – 4.65). When peer cannabis use and the cannabis use PRS were entered into the model simultaneously, the association between the cannabis use PRS and membership in high vs. moderate class was only slightly attenuated (OR: 1.46 [95% C.I. = [1.09, 1.94]; p = 0.010), as was the association with the high vs. no-low class comparison (OR: 1.34 [95% C.I. = [1.07, 1.68]; p = 0.012). Peer cannabis use was independently and significantly associated with all three comparisons in these models that also included the PRS as a predictor (both high vs. no-low and moderate vs. no-low p < 0.001, high vs. moderate p = 0.017).
