The cannabis use PRS was significantly associated with cannabis use trajectory class membership (Table 2). At the most significantly-associated PRS threshold of pT < 0.1, the cannabis use PRS explained approximately 1.4% of the conditional variance in high vs. no-low class membership (2.30% of the marginal variance); for every unit increase in PRS, membership in the high vs. no-low class increased by an odds of 1.40 (95% CI = [1.13, 1.74]) (Figure S2; full results for all thresholds in Table 2, all covariates in Table 3). Cannabis PRS also explained 3.6% of the conditional variance in high vs. moderate class membership, although this comparison did not survive Bonferroni correction (OR = 1.49, 95% CI = [1.12, 1.97], p = 0.006). There was no evidence that cannabis use PRS was associated with height at baseline (p = 0.730). Results from the BCH approach identified identically significant differences in mean PRS across the high class when compared with the moderate and the no-low class (Table S5).
