quality in the SardiNIA, NTRNESDA and ERF studies (r-squared or proper_info > 0.97). The MAFs were very similar across studies and ranged between 0.15 and 0.24. Furthermore, genotype and allele proportions of rs1477268 are in HWE in all studies (P > 0.01). The association of these two SNPs with Openness to Experience could not, however, be replicated (combined P across the replication samples 0.53 and 0.55 respectively for rs1477268 and rs2032794, combined P across discovery and replication samples 1.84 × 10−6 and 1.70 × 10−6).
