The two genome-wide significant SNPs for Openness to Experience (rs1477268, rs2032794, r-squared among SNPs ranges between 0.92 and 1 across studies) are located on chromosome 5q14.3 in an intergenic region 135kb downstream from the RASA1 gene (lowest P = 2.8 × 10−8, with an explained variance of 0.22%) (Figure 1a). The gene-based P value for RASA1 was 0.02. RASA1 codes for a GTPase activating protein involved in intracellular signaling and cellular proliferation and differentiation. The gene is highly expressed in the bone marrow and bone, and modestly in the brain.66 Further, Figure 2a shows that the effect for rs1477268 is in the same direction for nine of the ten studies. Heterogeneity in results across studies was not significant (χ2 = 9.15, df = 9, P = 0.42). The SNP was genotyped in seven of the studies and imputed with high quality in the SardiNIA, NTRNESDA and ERF studies (r-squared or proper_info > 0.97). The MAFs were very similar across studies and ranged between 0.15 and 0.24. Furthermore, genotype and allele proportions of rs1477268 are in HWE in all studies (P
