Among 8,861 self-identified white ARIC participants genotyped, 8,127 participants remained after exclusions for call rate<95%, genotypic and phenotypic sex mismatch, discordances with previous genotype data, suspected first-degree relative of an included individual based on genotype data, more than eight standard deviations for any of the first 10 principal components using EIGENSTRAT68, or outlying average identity-by-state estimates using PLINK69. Of these, 7,980 participants had pulmonary function measures and complete covariate information.
