Currently, two common CNV regions have been described for BMI and obesity. At first, association of a common deletion near the neuronal growth regulator 1 gene (NEGR1) with BMI was reported (8). Some CNVs are in strong linkage disequilibrium with adjacent SNPs; therefore, this CNV was detected in a meta-analysis of SNP data of 15 GWAS comprising more than 32 000 individuals. Recently, another common CNV (chromosome 10p11.22) was shown to be associated with BMI (19) in a Chinese sample (nominal P-value = 0.011).
