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Chunk #2 — The Tailoring of Interventions Based on One’s Genome

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Polygenic Score × Intervention Moderation: an Application of Discrete-Time Survival Analysis to Model the Timing of First Marijuana Use Among Urban Youth.
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Although Uhl and colleagues’ work has largely focused on smoking cessation treatment, Uhl et al. (2014) demonstrated that their quit success score could be also used to predict the initial and continuing course of the frequency of use of commonly addictive substances (tobacco, marijuana, and alcohol) in the aggregate from adolescence through young adulthood. Moreover, in an extension of Uhl et al. (2014), Musci and colleagues (2015b) examined the relationship between Uhl et al. (2014)’s quit success score and tobacco and marijuana trajectories, separately, in adolescence. Moreover, Musci et al. (2015b) examined the interaction between the score and a parallel trajectory of environmental risk/protective factors (parent monitoring and friends’ tobacco and marijuana use, respectively). Significant interactions were found between the score and the risk/protective factors trajectory for both marijuana and tobacco, separately.