test statistics in the results from any cohort (λGC = 0.97–1.05) (Supplementary Table 1). Meta-analysis of GWAS summary statistics was conducted using an inverse variance-weighted fixed effects model in METAL (version 2011-03-25)100 across 57 cohorts for the autosomes (41,917 BD cases and 371,549 controls) and 51 cohorts for the X chromosome (35,691 BD cases and 96,731 controls). A genome-wide significant locus was defined as the region around a SNP with P < 5 × 10−8, with linkage disequilibrium (LD) r2 > 0.1, within a 3,000 kilobase (kb) window. Regional association plots and forest plots of the index SNP for all genome-wide significant loci are presented in Supplementary Data 1 and 2, respectively.
