Rs1229984 in ADH1B was replicated in OZALC-EA for the primary AD phenotype (Table 3); in SAGE-AA for the secondary DSM-IV AD criterion count as well as for tertiary phenotypes of Desire to cut drinking in SAGE-AA, SAGE-EA, and OZALC-EA, and in SAGE-AA, for Tolerance. Meta-analysis of all available datasets enhanced significance across primary and tertiary phenotypes (Table 3). The association between rs188227250 and Drinking more than intended was replicated in OZALC-EA and a meta-analysis of EA, SAGE-EA, and OZALC-EA strengthened the association (p=3.71E-09, Table 3). Although rs1912461 on chromosome 15 was not significantly associated with Time spent drinking in either the SAGE-EA or OZALC-EA samples (p> 0.12), the direction of the effect was the same and meta-analysis across COGA and the replication samples retained significance for this variant (p=2.31E-08, Table 3). Variants on chromosomes 1 and 2 did not replicate in any dataset (all p>0.07 or opposite direction of effects; Table 3).
