Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Expressed in multiple tissues including brain. The finding lies close to linkage regions for autism (Szatmari et al. 2007b)Site known for CNVs.Another integrin-encoding gene ITGAE, also is listed under rank 28rs11594082521.00E-0510q22.172969259In intron of CDH23 Encodes cadherin-like 23, a member of the cadherin superfamily, whose genes encode calcium dependent cell–cell adhesion glycoproteins. Expressed in the neurosensory epithelium, the protein is thought to be involved in stereocilia organization and hair bundle formation; also expressed in brain. The gene is involved in deafness. Finding lies close to linkage region for bipolar disorder (1997). Gene shows association with schizophrenia at P values of 10−4 (Sullivan et al. 2008)rs7995215531.35E-0813q31.393206507In intron of GPC6 Encodes glypican 6. The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans. The glypicans have been implicated in the control of cell growth and division. Glypican 6 is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Expressed in multiple tissues including brain. SNPs in the close vicinity of this finding showed association at 10−4 in GWAS for bipolar disorder (Sklar et al. 2008). Gene shows association with schizophrenia (Sullivan et al.
