Our study reports a meta-analysis of GWAS results from 20,288 participants and follow-up analyses in 54,276 participants, identifying five novel genome-wide significant loci for pulmonary function. The regions identified were 4q24 (GSTCD), 2q35 (TNS1) and 5q33 (HTR4) for FEV1, and 6p21 (AGER) and 15q23 (THSD4) for FEV1/FVC. In addition, we identified a region suggestive of association with FEV1/FVC at 6p21 in DAAM2. The companion manuscript from the CHARGE Consortium, which reports a GWAS of lung function in 20,890 participants, also identifies genome-wide significant associations at GSTCD, HTR4 and AGER30. Both SpiroMeta and CHARGE confirmed the previously reported association between FEV1 and FEV1/FVC and the 4q31 locus upstream of HHIP11.
