ADHD PRS were negatively associated with non-problem cannabis use, and were positively associated with all levels of nicotine use (Supplementary Table S2). No associations remained significant after correction for multiple testing. Cannabis: Compared with nonusers, non-problem cannabis users (i.e., users with 0 symptoms) had lower ADHD PRS. Nicotine: Users at all levels of nicotine involvement (i.e., non-problem use, mild problems, and moderate and severe dependence) had elevated ADHD PRS relative to nonusers. Despite associations across increasing levels of nicotine involvement, the magnitude of these associations did not statistically differ from each other.
