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Chunk #15 — Material and Methods — Neuroimaging measures

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Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.
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targets despite the lack of incentive value. A feedback message then informed subjects of the trial outcome. The incentive trials were presented contiguously in a pseudorandom order. Subjects performed two runs of the task, each lasting 5 minutes. A total of twenty trials of each condition were recorded. The duration of the response target was calculated based on individual subject’s reaction time during a practice session prior to scanning. The allotted duration was calibrated such that the overall success rate was approximately 60%. Participants were paid a fixed rate to participate in the study and additionally received any money they won during the task. Reaction time and success rate for each incentive condition were calculated. Independent sample t-tests were used to assess possible performance differences between GABRA2 A-carriers and GG genotype groups for both SNPs and haplotypes.